Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019 - Institut Pierre Louis d'Epidémiologie et de Santé Publique
Article Dans Une Revue Clinical Infectious Diseases Année : 2021

Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019

Arsène Mékinian

Résumé

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.
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Dates et versions

hal-03704027 , version 1 (06-09-2024)

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Martin Martinot, Aude Jary, Samira Fafi-Kremer, Valentin Leducq, Heloise Delagreverie, et al.. Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019. Clinical Infectious Diseases, 2021, 73 (7), pp.e1762-e1765. ⟨10.1093/cid/ciaa1474⟩. ⟨hal-03704027⟩
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