RIPK1 inhibition in malignant cells potentiates immunotherapy and radiotherapy outcome
Résumé
Apoptosis, necroptosis and pro-inflammatory NF-κB-dependent signaling are repressed by receptorinteracting serine/threonine-protein kinase 1 (RIPK1). A recent paper in Immunity describes a small molecule inducing the proteolytic degradation of RIPK1. In preclinical experiments, this RIPK1 inhibitor improved the anticancer efficacy of radiotherapy, immunotherapy (with PD-1 blockade) and radioimmunotherapy (with CTLA-4 blockade).
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